Created by colleagues to save time through knowledge sharing. Join us now!

  • Create your personal profile, so colleagues can find you
  • Easily share your publications, video's, case-studies, blogs, presentations, posters, or other information
  • Your publications will be connected directly to PubMed
  • Join or start a discussion and invite colleagues
  • Find yourself in a secured online environment

Latest News

Genetic background of inflammatory bowel disease

News 3 weeks ago

A recent article in The Journal of Pathology highlights important causal genetic variants in the candidate genes NOD2, ATG16L1, IRGM, IL23R, CARD9, RNF186, and PRDM1 in the pathogenesis of inflammatory bowel disease (IBD). The investigators describe their downstream effects on […]

Ovarian cancer histology varies widely worldwide

News 4 weeks ago

The CONCORD programme is the largest population-based study of global trends in cancer survival. In a recent analysis, data on almost 700,000 women with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. The distribution […]

Apolipoprotein C-I plays a role in glomerulosclerosis

News 1 month ago

Diabetic nephropathy is the leading cause of end-stage renal disease. Diabetic patients have increased plasma concentrations of apoCI. A polymorphism in APOC1 was found to be associated with an increased risk of developing nephropathy. Some findings in mice and man […]

Delta-like ligand 4 modulates liver damage

News 1 month ago

Disrupting Notch signaling ameliorates experimental liver fibrosis. However, the role of individual Notch ligands in liver damage is unknown. An international research group investigated the effects of Delta-like ligand 4 (Dll4) in liver disease. Application of recombinant Dll4 protein (rDll4) […]

Molecular insights into tumour metastasis

News 1 month ago

A recent review in The Journal of Pathology provides an update on the regulation networks which are involved in the migration and colonisation of tumour cells to distant sites, such as epithelial-mesenchymal transition in local invasion, resistance to anoikis. The […]

Review about genomic discoveries in prostate cancer

News 1 month ago

Genomic discoveries in prostate cancer (PCa) are changing the treatment landscape of advanced castration-resistant PCa (CRPC), both by identifying biomarkers of resistance and by identifying vulnerabilities to be targeted. A recent review summarised these developments.¬†PCa is a heterogeneous disease and […]

Prostate cancer is sometimes by MR- and ultrasound-guided biopsy

News 1 month ago

Both magnetic resonance (MR)- and transrectal ultrasound (TRUS)-guided biopsy (Bx) have difficulties in detecting apical lesions. MR-Bx most often missed cancer with involvement of the dorsolateral part (58%) and TRUS-Bx with involvement of the anterior part (79%). Knowledge of significant […]

Different miRNAs are targets in colorectal cancer metastasis

News 1 month ago

It remains poorly characterised how colorectal cancer cells metastasize to the liver. A recent study addressed the role of dysregulation of microRNA (miRNA) in metastasis.¬†Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to […]